BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
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چکیده
منابع مشابه
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance.
Mutations in the BCR/ABL kinase domain play a major role in resistance to imatinib mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species (ROS), which causes oxidative DNA damage, resulting in mutations in the kinase domain. The majority of mutations involved A/T-->G/C and G/C-->A/T transitions, a phenotype detected previously in patients, which encoded clinically ...
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ژورنال
عنوان ژورنال: Blood
سال: 2006
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2005-07-2815